TRIGGERS OF MAST CELL DEGRANULATION
By Gary M. White, MD
Non steroidal anti-inflammatory drugs
Opiates (e.g. morphine, codeine)
Dextromethorphan which is related to codeine can also cause degranulation and can be found in over-the-counter cough syrups for children [PD 1996;13;410].
Iodine-containing radiographic contrast media
Other possible precipitants of mast cell degranulation
Physical stimuli such as extreme temperature changes, friction, heat, cold.
Stings, e.g. bee, jellyfish.
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