TRIGGERS OF MAST CELL DEGRANULATION

By Gary M. White, MD

Drugs

Aspirin

Non steroidal anti-inflammatory drugs

Opiates (e.g. morphine, codeine)

Dextromethorphan which is related to codeine can also cause degranulation and can be found in over-the-counter cough syrups for children [PD 1996;13;410].

Alcohol

Iodine-containing radiographic contrast media

Polymyxin B

Scopolomine, d-tubocurarine

Other possible precipitants of mast cell degranulation

Physical stimuli such as extreme temperature changes, friction, heat, cold.

Stings, e.g. bee, jellyfish.

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